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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10989719 B1

PDFFull Text
Date of Patent:
Apr. 27, 2021

Filed:

Oct. 10, 2014

Methods for treating spinocerebellar ataxia type i using rpa1

Applicant:

National University Corporation Tokyo Medical and Dental University, Tokyo, JP;

Inventor:

Hitoshi Okazawa, Tokyo, JP;

Assignee:

National University Corporation Tokyo Medical and Dental University, Tokyo, JP;

Attorney:

Sughrue Mion, PLLC

Primary Examiner:

Chang-Yu Wang

Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61K 49/00 (2006.01); C07K 14/00 (2006.01); C12N 15/63 (2006.01); C12N 5/10 (2006.01); C12N 15/00 (2006.01); C12N 15/11 (2006.01); G01N 33/68 (2006.01); C12Q 1/48 (2006.01); G01N 33/50 (2006.01); A61K 31/5377 (2006.01); A61K 31/553 (2006.01); A61K 31/519 (2006.01); A61K 31/4748 (2006.01); A61K 31/465 (2006.01); A61K 31/4704 (2006.01); A61K 45/06 (2006.01); A61K 31/497 (2006.01); A61P 25/28 (2006.01); A61P 25/00 (2006.01); A61K 38/04 (2006.01); A61K 38/16 (2006.01); A61K 38/17 (2006.01); C12N 7/00 (2006.01); C12Q 1/6897 (2018.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6896 (2013.01); A61K 31/465 (2013.01); A61K 31/4704 (2013.01); A61K 31/4748 (2013.01); A61K 31/497 (2013.01); A61K 31/519 (2013.01); A61K 31/5377 (2013.01); A61K 31/553 (2013.01); A61K 38/00 (2013.01); A61K 38/04 (2013.01); A61K 38/16 (2013.01); A61K 38/1709 (2013.01); A61K 45/06 (2013.01); A61K 49/0058 (2013.01); A61P 25/00 (2018.01); A61P 25/28 (2018.01); C12N 7/00 (2013.01); C12Q 1/485 (2013.01); C12Q 1/6897 (2013.01); G01N 33/5058 (2013.01); A61K 48/00 (2013.01); C12N 2750/14143 (2013.01); C12N 2750/14171 (2013.01); G01N 2800/28 (2013.01); G01N 2800/2821 (2013.01); G01N 2800/2835 (2013.01);
Abstract

To provide a compound which enables treatment or prevention of spinocerebellar ataxia, analyses were carried out based on a screening using a spinocerebellar ataxia type 1 (SCA1) fly model and on the like. As a result, the following proteins ameliorating the pathology of spinocerebellar ataxia were identified: RPA1, PNKP, XRCC3, XRCC4, CCNH, POLE, POLH, and PER1. On the other hand, the following proteins aggravating the pathology were identified: CHK1, LIG3, FEN1, LIG1, ERCC5, XAB2, ERCC2, DMC1, RECQL5, MUS81, EME1, SPO11, and BLM. In addition, it has been revealed that ATXN1, which is a cause of SCA1, binds to RPA1, BRCA1, and BRCA2, and suppresses the activities of these proteins, so that the above-described pathology is caused.

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