The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 27, 2021
Filed:
Jun. 06, 2017
Applicant:
Alexion Pharmaceuticals, Inc., Boston, MA (US);
Inventors:
Saravanamoorthy Rajendran, Middletown, CT (US);
Rachael Alford, Guilford, CT (US);
Sean Gallagher, Naas, IE;
Anne Kantardjieff, Milford, CT (US);
Jared Davis, Hamden, CT (US);
Assignee:
Alexion Pharmaceuticals, Inc., Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/16 (2006.01); C12Q 1/44 (2006.01);
U.S. Cl.
CPC ...
C12N 9/16 (2013.01); C12Q 1/44 (2013.01); C12Y 301/03001 (2013.01);
Abstract
The disclosure provides a method of producing recombinant alkaline phosphatase comprising: (i) culturing an alkaline phosphatase in a recombinant cell culture; (ii) obtaining a preparation of recombinant alkaline phosphatase from the cell culture; and (iii) minimizing in the preparation a concentration of at least one metal ion selected from the group consisting of: Nickel (Ni), Cobalt (Co), Copper (Cu), Manganese (Mn), Chromium (Cr), and Molybdenum (Mo).