The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 27, 2021

Filed:

Jan. 15, 2016
Applicants:

Clemson University Research Foundation, Clemson, SC (US);

Musc Foundation for Research Development, Charleston, SC (US);

The University of Chicago, Chicago, IL (US);

Inventors:

Ying Mei, Mount Pleasant, SC (US);

Tan Yu, Charleston, SC (US);

Dylan Richards, Charleston, SC (US);

Donald R. Menick, Isle of Palms, SC (US);

Bozhi Tian, Chicago, IL (US);

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/077 (2010.01); G01N 33/50 (2006.01); A61K 35/34 (2015.01); A61L 27/30 (2006.01); A61L 27/38 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0657 (2013.01); A61K 35/34 (2013.01); A61L 27/306 (2013.01); A61L 27/3804 (2013.01); A61L 27/3826 (2013.01); A61L 27/3886 (2013.01); G01N 33/5061 (2013.01); A61L 2400/12 (2013.01); A61L 2430/20 (2013.01); C12N 2503/02 (2013.01); C12N 2506/45 (2013.01); C12N 2513/00 (2013.01); C12N 2533/10 (2013.01);
Abstract

Described herein are tissues containing semiconductor nanomaterials. In some embodiments, the tissues include vascular cells, cardiomyocytes, and/or cardiac fibroblasts. The tissue may be scaffold-free. In some embodiments, the tissue includes an electrically conductive network. The tissue may exhibit synchronized electrical signal propagation within the tissue. In some embodiments, the tissue exhibits increased functional assembly of cardiac cells and/or increased cardiac specific functions compared to a cardiac tissue prepared using a conventional tissue culture method. Methods of preparing and using such tissues are also described herein.


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