The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 27, 2021

Filed:

Oct. 05, 2018
Applicant:

Emulate, Inc., Boston, MA (US);

Inventors:

Daniel Levner, Brookline, MA (US);

Josiah Daniel Sliz, Boston, MA (US);

Christopher David Hinojosa, Malden, MA (US);

Joshua Gomes, Cambridge, MA (US);

Jose Fernandez-Alcon, Cambridge, MA (US);

Assignee:

EMULATE, Inc., Boston, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 1/10 (2006.01); G01N 7/00 (2006.01); G01N 35/08 (2006.01); G01N 35/02 (2006.01); C12M 3/06 (2006.01); B01L 3/00 (2006.01); C12M 1/00 (2006.01); C12M 1/42 (2006.01); C12M 1/34 (2006.01); C12N 5/071 (2010.01); A01N 1/02 (2006.01); C12M 3/00 (2006.01); C12M 1/36 (2006.01); B01L 9/00 (2006.01);
U.S. Cl.
CPC ...
C12M 23/16 (2013.01); A01N 1/021 (2013.01); A01N 1/0247 (2013.01); B01L 3/50273 (2013.01); B01L 3/502707 (2013.01); B01L 3/502715 (2013.01); B01L 3/502738 (2013.01); B01L 9/527 (2013.01); C12M 21/08 (2013.01); C12M 23/38 (2013.01); C12M 23/40 (2013.01); C12M 23/42 (2013.01); C12M 29/10 (2013.01); C12M 35/04 (2013.01); C12M 41/40 (2013.01); C12M 41/48 (2013.01); C12N 5/0602 (2013.01); B01L 2200/025 (2013.01); B01L 2200/027 (2013.01); B01L 2200/12 (2013.01); B01L 2300/0681 (2013.01); B01L 2300/0887 (2013.01); B01L 2300/123 (2013.01); B01L 2300/14 (2013.01); B01L 2300/161 (2013.01); B01L 2300/165 (2013.01); B01L 2400/0481 (2013.01); B01L 2400/0487 (2013.01); B01L 2400/06 (2013.01); C12N 2521/00 (2013.01);
Abstract

A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body. A method for pressure control is contemplated to allow the control of flow rate (while perfusing cells) despite limitations of common pressure regulators. The method for pressure control allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly, so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.


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