The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 27, 2021
Filed:
Aug. 24, 2016
Applicant:
Cellectis, Paris, FR;
Inventors:
Assignee:
CELLECTIS, Paris, FR;
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/725 (2006.01); C07K 14/72 (2006.01); C07K 16/28 (2006.01); A61K 35/17 (2015.01); A61P 35/00 (2006.01); A61K 31/436 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2869 (2013.01); A61K 31/436 (2013.01); A61K 35/17 (2013.01); A61P 35/00 (2018.01); C07K 14/7051 (2013.01); C07K 14/721 (2013.01); C07K 16/2803 (2013.01); A61K 38/00 (2013.01); C07K 2317/622 (2013.01); C07K 2319/03 (2013.01); C12N 2510/00 (2013.01);
Abstract
The present invention relates to the field of cell immunotherapy and more particularly to a new generation of chimeric antigen receptors (CAR), allowing the control of immune cells endowed with such CARs through the interaction with small molecules. More particularly, the present invention relates to chimeric antigen receptor which comprise in at least one ectodomain a molecular switch turning the antigen binding function of the receptor from an off to on state, and vice versa. The present invention thus provides more controlled and potentially safer engineered CAR endowed immune cells, such as T-lymphocytes.