The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 27, 2021

Filed:

Jan. 28, 2019
Applicants:

Merck Patent Gmbh, Darmstadt, DE;

Vertex Pharmaceuticals Incorporated, Boston, MA (US);

Inventors:

Andrew Bayly, Abingdon, GB;

Matthew Bleich, Brighton, MA (US);

Jean-Damien Charrier, Wantage, GB;

James Dodd, Abingdon, GB;

Steven Durrant, Abingdon, GB;

Meredith Suzanne Eno, Brighton, MA (US);

Gorka Etxebarria I Jardi, Abingdon, GB;

Simon Everitt, Abingdon, GB;

Damien Fraysse, Abingdon, GB;

Shazia Kelly, Abingdon, GB;

Ronald Knegtel, Abingdon, GB;

Igor Mochalkin, Westford, MA (US);

Michael Mortimore, Burford, GB;

Kiri North, Abingdon, GB;

Filippos Porichis, Melrose, MA (US);

Robert Pullin, Abingdon, GB;

Alistair Rutherford, Abingdon, GB;

Pierre-Henri Storck, Abingdon, GB;

Heather Clare Twin, Wantage, GB;

Yufang Xiao, Lexington, MA (US);

Assignees:

Merck Patent GmbH, Darmstardt, DE;

Vertex Pharmaceuticals Incorporated, Boston, MA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); A61K 31/5025 (2006.01); A61P 35/00 (2006.01); C07D 513/04 (2006.01); C07D 519/00 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61P 35/00 (2018.01); C07D 513/04 (2013.01); C07D 519/00 (2013.01);
Abstract

The present invention provides compounds inhibiting General amino acid Control Non-derepressible 2 kinase ('GCN2'), compositions thereof, and methods of using the same for treating various disorders, such as cancer.


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