The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 27, 2021
Filed:
Oct. 21, 2016
The Regents of the University of Michigan, Ann Arbor, MI (US);
Poznan University of Medical Sciences, Poznan, PL;
Joerg Lahann, Ann Arbor, MI (US);
Sywe-Ren Chang, Ann Arbor, MI (US);
Brian Clarkson, Ann Arbor, MI (US);
Nathan A. Jones, Ann Arbor, MI (US);
Agata Czajka-Jakubowska, Poznan, PL;
THE REGENTS OF THE UNIVERSITY OF MICHIGAN, Ann Arbor, MI (US);
POZNAN UNIVERSITY OF MEDICAL SCIENCES, Poznan, PL;
Abstract
Components, for example, nanoparticles for detecting and/or treating one or more active carious lesions or microcavities in teeth of a subject are provided. The component or nanoparticle may comprise a biocompatible and biodegradable polymer (e.g., a starch) bearing at least one cationic region and/or having a net positive charge and thereby capable of associating with one or more active and/or early carious lesions on a tooth in an oral cavity of a subject. The components or nanoparticles are optionally water soluble or dispersible. The components or nanoparticle also comprises an imaging agent (e.g., a fluorophore or dye) bonded to the biocompatible and biodegradable polymer. The component or nanoparticle is thus capable of indicating the presence of one or more active carious lesions when the component or nanoparticle is associated therewith. Oral care compositions comprising such compounds/nanoparticles and methods of making and using the same are also provided.