The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 27, 2021
Filed:
Nov. 24, 2017
Mabwell (Shanghai) Bioscience Co., Ltd., Shanghai, CN;
Jiangsu Mabwell Health Pharmaceutical R&d Co., Ltd., Jiangsu, CN;
Jingkang Shen, Shanghai, CN;
Tao Meng, Shanghai, CN;
Lanping Ma, Shanghai, CN;
Xin Wang, Shanghai, CN;
Hongli Peng, Shanghai, CN;
Yongliang Zhang, Shanghai, CN;
Ting Yu, Shanghai, CN;
Lin Chen, Shanghai, CN;
Zhiyan Du, Shanghai, CN;
Ying Wang, Shanghai, CN;
Mabwell (Shanghai) Bioscience Co., Ltd., Shanghai, CN;
Jiangsu Mabwell Health Pharmaceutical R&D Co., Ltd., Jiangsu, CN;
Abstract
Provided in the present invention are a di-substituted maleic amide linker conjugated to an antibody and a preparation method and use thereof. In particular, the present invention conjugates a strongly cytotoxic active substance to a biomacromolecule through a class of new linkers. The class of linkers can selectively act simultaneously with disulphide chains, so as to greatly improve the substance homogeneity of a conjugate. The conjugate prepared by the linker of the present invention has a high inhibitory activity on a cell strain expressing the corresponding antigen. Also provided is a method for preparing the above-mentioned conjugate and the use.