The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 27, 2021

Filed:

Mar. 20, 2017
Applicant:

Kansas State University Research Foundation, Manhattan, KS (US);

Inventor:

Weiping Zhang, Manhattan, KS (US);

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 39/02 (2006.01); A61K 39/108 (2006.01); C07K 14/245 (2006.01); C07K 19/00 (2006.01); A61P 31/04 (2006.01);
U.S. Cl.
CPC ...
A61K 39/0258 (2013.01); A61P 31/04 (2018.01); C07K 14/245 (2013.01); C07K 19/00 (2013.01); A61K 2039/6037 (2013.01); A61K 2039/70 (2013.01); C07K 2319/40 (2013.01); Y02A 50/30 (2018.01);
Abstract

The application provides for MEFA constructs and vaccines against Enterotoxigenic(ETEC). Methods for reducing the incidence of diarrhea associated with ETEC are also provided. The representative adhesin tip MEFAs and the representative major subunit CFA MEFA-II provided in the disclosure has an adhesin tip backbone or major subunit CFA with one or more adhesin tips, adhesin subunit or major structural subunit epitopes incorporated onto the backbone. The adhesin tip MEFAs and the CFA MEFA-II provided advantageously prevents the ETEC molecule from attaching to the intestine.


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