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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10987409 B1

PDFFull Text
Date of Patent:
Apr. 27, 2021

Filed:

Sep. 20, 2019

Compositions and methods for improved encapsulation of functional proteins in polymeric vesicles

Applicant:

Poseida Therapeutics, Inc., San Diego, CA (US);

Inventors:

P. Peter Ghoroghchian, Boston, MA (US);

Jivan Namdeo Yewle, Lexington, KY (US);

Assignee:

POSEIDA THERAPEUTICS, INC., San Diego, CA (US);

Attorneys:

Cooley LLP

Ivor Elrifi

Matthew Pavao

Primary Examiner:

Anand U Desai

Int. Cl.
CPC ...
A61K 38/42 (2006.01); A61K 9/127 (2006.01); A61K 9/10 (2006.01);
U.S. Cl.
CPC ...
A61K 38/42 (2013.01); A61K 9/10 (2013.01); A61K 9/1273 (2013.01);
Abstract

Methods of preparing polymersome-encapsulated functional protein suspensions may include thermally blending an amount of a block copolymer with an amount of a low molecular weight polyethylene glycol (PEG) for at least 30 minutes, mixing and cooling a resulting PEG/polymer formulation to room temperature, adding an aliquot of a solution of the functional protein to a sample containing the PEG/polymer formulation, and performing at least three dilution steps in which polymersomes that are generated are progressively saturated with the functional protein. The aliquot of the solution of the functional protein added may have a to the PEG/polymer sample of around 0.5:1 to 1.5:1 by volume, and the thermal blending may be performed at 90-100° C.

Find Patent Forward Citations

Ghoroghchian, P.. (2021). Compositions and methods for improved encapsulation of functional proteins in polymeric vesicles (U.S. Patent No. 10987409). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10987409

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