The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 27, 2021
Filed:
Jan. 13, 2020
Applicant:
Cornell University, Ithaca, NY (US);
Inventors:
Richard A. Cerione, Ithaca, NY (US);
Jon W. Erickson, Freeville, NY (US);
Kristin Wilson Cerione, Ithaca, NY (US);
Jianbin Wang, Ithaca, NY (US);
Assignee:
Cornell University, Ithaca, NY (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/473 (2006.01); A61K 31/00 (2006.01); C07D 471/04 (2006.01); C07D 249/12 (2006.01); C07D 239/62 (2006.01); C07D 277/06 (2006.01); C07D 221/18 (2006.01); A61K 31/4745 (2006.01);
U.S. Cl.
CPC ...
A61K 31/00 (2013.01); A61K 31/4745 (2013.01); C07D 221/18 (2013.01); C07D 239/62 (2013.01); C07D 249/12 (2013.01); C07D 277/06 (2013.01); C07D 471/04 (2013.01);
Abstract
The present invention relates to a method of reducing the production of glutamate from glutamine by glutaminase C in a cell or tissue. The method involves inhibiting glutaminase C activity in the cell or tissue under conditions effective to reduce production of glutamate from glutamine. Compounds for carrying out this method are also disclosed.