The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 20, 2021

Filed:

Mar. 06, 2019
Applicant:

Qingdao University, Qingdao, CN;

Inventors:

Hui Jin, Qingdao, CN;

Rijun Gui, Qingdao, CN;

Xiangning Bu, Qingdao, CN;

Yongxin Fu, Qingdao, CN;

Assignee:

QINGDAO UNIVERSITY, Qingdao, CN;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 21/64 (2006.01); A61K 31/167 (2006.01); B82Y 5/00 (2011.01);
U.S. Cl.
CPC ...
G01N 21/6428 (2013.01); A61K 31/167 (2013.01); B82Y 5/00 (2013.01); G01N 2021/6432 (2013.01);
Abstract

A method for preparing a ratiometric fluorescent sensor for paracetamol based on a copper nanoclusters-carbon dots-arginine composite is provided. Copper nanoclusters CuNCs with red fluorescence are bonded to carbon dots (CDs) with blue fluorescence by electrostatic adsorption and hydrogen bonding, and then arginine is added to form the CuNCs-CDs-arginine composite. The addition of arginine leads to a significant decrease in the blue fluorescence of the CDs, while after the paracetamol is added, the blue fluorescence of the CDs gradually recovered as a result of the specific binding of arginine to paracetamol. The ratiometric fluorescent sensor for paracetamol is constructed by taking the fluorescence of the CuNCs as a reference signal, and the fluorescence of the CDs as a response signal, and fitting the linear relationship between the ratios I/Iof fluorescence emission peak intensities of CDs and CuNCs and the molar concentrations of paracetamol.


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