The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 20, 2021
Filed:
Nov. 20, 2018
Mendel Biotechnology, Inc., Hayward, CA (US);
Roger Canales, San Diego, CA (US);
Shiv Tiwari, San Jose, CA (US);
T. Lynne Reuber, San Mateo, CA (US);
Karen S. Century, Chapel Hill, NC (US);
Oliver J. Ratcliffe, Oakland, CA (US);
Mendel Biotechnology, Inc., Hayward, CA (US);
Abstract
A new and strong transcriptional activation domain was identified from theprotein Ethylene Response Factor 98 (AtERF98). This domain has been designated as the 'EDLL domain' and has a number of highly conserved amino acid residues that are found throughout the members of the AtERF98 family from plants, including in monocot and eudicot orthologs. The EDLL domain was shown to be highly active when it was fused to transcription factors from plant and yeast, and was also shown to have activation potential comparable to the widely-used VP16 activation domain derived from. The EDLL domain was also active when it was targeted to a gene promoter by a sequence-specific DNA binding protein or by protein-protein interactions. Unlike other known activation domains such as VP16 and GAL4, the EDLL domain is relatively small in size, and being of plant origin, it is favored as a strong transcriptional activation tool for application in transgenic food crops.