The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 20, 2021
Filed:
May. 05, 2017
Applicant:
Jiangsu Micromedmark Biotech Co., Ltd., Jiangsu, CN;
Inventors:
Chenyu Zhang, Jiangsu, CN;
Xi Chen, Jiangsu, CN;
Hongwei Liang, Jiangsu, CN;
Uzair Ur-Rehman, Jiangsu, CN;
Ke Zeng, Jiangsu, CN;
Assignee:
JIANGSU MICROMEDMARK BIOTECH CO., LTD., Jiangsu, CN;
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); A61K 31/7088 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1137 (2013.01); A61K 31/7088 (2013.01); C12N 2310/141 (2013.01); C12N 2320/30 (2013.01);
Abstract
The present invention discloses an siRNA that inhibits K-RAS gene expression, and the precursor sequences and applications thereof. The K-RAS siRNA and its precursor sequences provided by the present invention can efficiently inhibit the expression of the K-RAS gene, and in vivo experiments have shown that the K-RAS siRNA has a certain inhibitory effect on tumours highly expressing K-RAS. The precursor of the siRNA of the invention and its vector can form a stable siRNA that functions in a host.