The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 20, 2021
Filed:
Dec. 04, 2015
Applicant:
Merck Patent Gmbh, Darmstadt, DE;
Inventors:
Gordana Wozniak-Knopp, Vienna, AT;
Sylvia Dietrich, Vienna, AT;
Florian Rüker, Vienna, AT;
Alec Gross, Newton, MA (US);
Stefan Becker, Darmstadt, DE;
Assignee:
MERCK PATENT GMBH, Darmstadt, DE;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/46 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
C07K 16/468 (2013.01); C07K 16/283 (2013.01); C07K 16/2809 (2013.01); C07K 16/2863 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/35 (2013.01); C07K 2317/526 (2013.01); C07K 2317/55 (2013.01); C07K 2317/64 (2013.01); C07K 2317/66 (2013.01); C07K 2317/71 (2013.01); C07K 2317/73 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01);
Abstract
The invention provides for a domain-exchanged antibody comprising a light chain (LC) composed of VL-CH3, and a heavy chain (HC) comprising VH-CH3-CH2-CH3, wherein the VL-CH3 of the LC is dimerising with the VH-CH3 of the HC thereby forming a domain-exchanged LC/HC dimer comprising a CH3LC/CH3HC domain pair, and means and method for producing the same.