The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 20, 2021

Filed:

Mar. 21, 2017
Applicant:

Roche Diagnostics Operations, Inc., Indianapolis, IN (US);

Inventors:

Michael Gerg, Munich, DE;

Dieter Heindl, Paehl, DE;

Christian Klein, Bonstetten, CH;

Alfred Mertens, Schriesheim, DE;

Volker Schmid, Penzberg, DE;

Michael Schraeml, Penzberg, DE;

Monika Soukupova, Wessobrunn, DE;

Michael Tacke, Munich, DE;

Assignee:

Roche Diagnostics Operations, Inc., Indianpolis, IN (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/46 (2006.01); G01N 33/531 (2006.01);
U.S. Cl.
CPC ...
C07K 16/468 (2013.01); G01N 33/531 (2013.01);
Abstract

A bivalent binding agent having a first monovalent binder that binds to a polypeptide epitope of a target polypeptide, a second monovalent binder that binds to a posttranslational polypeptide modification on the target polypeptide and a linker. Further disclosed are methods for the detection of a posttranslationally modified target polypeptide, for making the disclosed bivalent binding agent, and for use of the disclosed bivalent binding agent in histological staining procedures.


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