The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 20, 2021
Filed:
Feb. 06, 2018
Applicant:
Stichting Sanquin Bloedvoorziening, Amsterdam, NL;
Inventor:
Timo Kars Van Den Berg, Amsterdam, NL;
Assignee:
Stichting Sanquin Bloedvoorziening, Amsterdam, NL;
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61K 39/12 (2006.01); A61K 39/275 (2006.01); C07K 16/30 (2006.01); A61K 39/395 (2006.01); C07K 16/32 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2803 (2013.01); A61K 39/12 (2013.01); A61K 39/275 (2013.01); A61K 39/395 (2013.01); A61K 39/3955 (2013.01); C07K 16/2863 (2013.01); C07K 16/2887 (2013.01); C07K 16/2893 (2013.01); C07K 16/30 (2013.01); C07K 16/32 (2013.01); A61K 2039/507 (2013.01); A61K 2039/57 (2013.01); A61K 2039/572 (2013.01); C07K 2317/21 (2013.01); C07K 2317/24 (2013.01); C07K 2317/732 (2013.01); C07K 2317/76 (2013.01); C07K 2317/77 (2013.01); C12N 2710/24034 (2013.01); C12N 2710/24134 (2013.01);
Abstract
The invention relates to the field of molecular medicine. In particular, it relates to compositions and methods to enhance the clearance of aberrant cells, e.g. cancer cells or virus-infected cells, by the host's immune system. Provided is a composition comprising (i) a therapeutic compound that can trigger a host's immune effector cells against an aberrant cell, such as a therapeutic antibody, and (ii) at least one agent capable of reducing or preventing inhibitory signal transduction initiated via SIRPalpha.