The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 20, 2021
Filed:
May. 17, 2017
Bayer Aktiengesellschaft, Leverkusen, DE;
Bayer Pharma Aktiengesellschaft, Berlin, DE;
The Broad Institute, Inc., Cambridge, MA (US);
Sarah Anna Liesa Johannes, Duesseldorf, DE;
Philipp Buchgraber, Berlin, DE;
Ulrich Klar, Berlin, DE;
Clara Christ, Berlin, DE;
Kai Thede, Berlin, DE;
Joachim Kuhnke, Potsdam, DE;
Manfred Moewes, Berlin, DE;
Knut Eis, Berlin, DE;
Amaury Fernandez-Montalvan, Le Pecq, FR;
Nicolas Werbeck, Berlin, DE;
Ursula Moenning, Woltersdorf, DE;
Philip Lienau, Potsdam, DE;
Ulrike Sack, Berlin, DE;
Arne Scholz, Berlin, DE;
Michael H. Serrano-Wu, Cambridge, MA (US);
Chris Lemke, Cambridge, MA (US);
David McKinney, Cambridge, MA (US);
Mark Fitzgerald, Cambridge, MA (US);
Christopher Nasveschuk, Cambridge, MA (US);
Kiel Lazarski, Cambridge, MA (US);
Steven James Ferrara, Cambridge, MA (US);
Laura Furst, Cambridge, MA (US);
Guo Wei, Cambridge, MA (US);
Patrick R. McCarren, Cambridge, MA (US);
Bayer Aktiengesellschaft, Leverkusen, DE;
Bayer Pharma Aktiengesellschaft, Berlin, DE;
The Broad Institute, Inc., Cambridge, MA (US);
Abstract
The present invention relates to macrocyclic indole derivatives of general formula (I): in which R, R, R, R, R, R, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical 2019 compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.