The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 20, 2021
Filed:
Jun. 03, 2017
National Center for Geriatrics and Gerontology, Obu, JP;
Masaaki Suzuki, Obu, JP;
Kengo Ito, Obu, JP;
Atsushi Natsume, Obu, JP;
Hiroshi Ikenuma, Obu, JP;
Hiroko Koyama, Gifu, JP;
Abstract
An object of the invention is to provide aC-labeled O-benzylguanine capable of obtaining a PET image and a process for producing the same. TheC-labeled O-benzylguanine of the invention is represented by the following chemical formula (a). TheC-labeled O-benzylguanine is produced by: a coupling step of cross-coupling a methyl iodide labeled withC and the following organotin compound (b) (Rrepresents an alkyl group, and Rand Rrepresent a leaving group which can be eliminated with a base) in the presence of a palladium complex, a phosphine ligand, and cuprous halide in an aprotic lactam; and a desorption step of desorbing the leaving groups Rand Rof the coupling product obtained by the coupling step with a base.