The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 20, 2021

Filed:

May. 19, 2020
Applicants:

Abbvie Overseas S.á.r.l., Luxembourg, LU;

Galapagos NV, Mechelen, BE;

Inventors:

Robert J. Altenbach, Chicago, IL (US);

Andrew Bogdan, Evanston, IL (US);

Sylvain Couty, Gentilly, FR;

Nicolas Desroy, Massy, FR;

Gregory A. Gfesser, Lindenhurst, IL (US);

Christopher Gaëtan Housseman, Montreuil, FR;

Philip R. Kym, Libertyville, IL (US);

Bo Liu, Waukegan, IL (US);

Thi Thu Trang Mai, Romainville, FR;

Karine Fabienne Malagu, Saffron Walden, GB;

Nuria Merayo Merayo, Paris, FR;

Olivier Laurent Picolet, Romainville, FR;

Mathieu Rafaël Pizzonero, Voisins le Bretonneaux, FR;

Xenia B. Searle, Grayslake, IL (US);

Steven Emiel Van der Plas, Steenhuffel, BE;

Xueqing Wang, San Carlos, CA (US);

Ming C. Yeung, Grayslake, IL (US);

Assignees:

AbbVie Overseas S.à.r.l., Luxembourg, LU;

Galapagos NV, Mechelen, BE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/04 (2006.01); C07C 311/45 (2006.01); C07D 213/30 (2006.01); C07D 213/64 (2006.01); C07D 213/71 (2006.01); C07D 215/36 (2006.01); C07D 231/56 (2006.01); C07D 235/28 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 471/04 (2006.01); A61P 1/00 (2006.01); A61P 11/00 (2006.01);
U.S. Cl.
CPC ...
C07D 401/04 (2013.01); A61P 1/00 (2018.01); A61P 11/00 (2018.01); C07C 311/45 (2013.01); C07D 213/30 (2013.01); C07D 213/64 (2013.01); C07D 213/71 (2013.01); C07D 215/36 (2013.01); C07D 231/56 (2013.01); C07D 235/28 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 471/04 (2013.01);
Abstract

The invention discloses compounds of Formula (I), wherein A, R, R, R, R, and n are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.


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