The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 20, 2021

Filed:

Sep. 08, 2017
Applicant:

Academy of Military Medical Sciences, Beijing, CN;

Inventors:

Hui Wang, Beijing, CN;

Tao Li, Beijing, CN;

Zhenyuan Miao, Beijing, CN;

Jianxin Wang, Beijing, CN;

Deyan Luo, Beijing, CN;

Jie Huang, Beijing, CN;

Chunlin Zhuang, Beijing, CN;

Yuelin Wu, Beijing, CN;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 213/79 (2006.01); C07D 213/80 (2006.01); C07D 213/803 (2006.01); A61P 31/04 (2006.01); A61K 31/455 (2006.01); A61K 31/44 (2006.01);
U.S. Cl.
CPC ...
C07D 213/803 (2013.01); A61K 31/44 (2013.01); A61K 31/455 (2013.01); A61P 31/04 (2018.01); C07D 213/79 (2013.01); C07D 213/80 (2013.01);
Abstract

Disclosed are a nicotinic acid or isonicotinic acid compound and a use thereof. The compound is the compound shown in Formula I, or a pharmaceutically acceptable salt, ester or solvate thereof. Efficacy tests demonstrate that the nicotinic acid compound can inhibittoxin endopeptidase activity in vitro, and has a significant protective effect on mice poisoned withtoxin. On this basis, the compound may be used to prepare a drug preventing and/or treatingtoxin exposure and/or poisoning.


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