The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 20, 2021

Filed:

Sep. 26, 2016
Applicant:

Pain Therapeutics, Inc., Austin, TX (US);

Inventors:

Remi Barbier, Austin, TX (US);

Nadav Friedmann, Georgetown, TX (US);

Vijay Srirambhatla, Edinburgh, GB;

Stephen Watt, East Lothian, GB;

Michael Zamloot, Austin, TX (US);

Assignee:

Pain Therapeutics, Inc., Austin, TX (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/485 (2006.01); A61K 9/70 (2006.01); C07D 489/08 (2006.01); C07C 59/285 (2006.01); C07C 55/10 (2006.01); A61K 31/4468 (2006.01);
U.S. Cl.
CPC ...
A61K 31/485 (2013.01); A61K 9/7038 (2013.01); A61K 31/4468 (2013.01); C07C 55/10 (2013.01); C07C 59/285 (2013.01); C07D 489/08 (2013.01);
Abstract

This invention relates to crystalline salts of naloxone and of naltrexone and their use as opioid antagonists. The crystalline salts of the invention include naloxone saccharinate, naltrexone succinate and a methanol solvate of naltrexone succinate. A drug-in-adhesive transdermal patch containing the opioid analgesic fentanyl or an analog thereof and a crystalline salts of naloxone or naltrexone is disclosed. Also disclosed is a method of treating pain, such as acute, chronic or intermittent pain, by applying a drug-in-adhesive transdermal patch of the invention to the skin of a patient in need thereof.


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