The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 20, 2021
Filed:
Jul. 03, 2019
Taiwan Liposome Company, Ltd., Taipei, TW;
Tlc Biopharmaceuticals, Inc., South San Francisco, CA (US);
Pei Kan, Taipei, TW;
ChiaHung Hung, Taipei, TW;
Keelung Hong, South San Francisco, CA (US);
Yun-Long Tseng, Taoyuan, TW;
Yung-Hsu Chan, Taipei, TW;
TAIWAN LIPOSOME COMPANY, LTD., Taipei, TW;
TLC BIOPHARMACEUTICALS, INC., South San Francisco, CA (US);
Abstract
Provide is a method of using a topoisomerase I inhibitor in treatment of cancer to reduce bone marrow suppression. The method includes administering to a subject in need thereof an effective amount of a pharmaceutical composition. The composition has at least one hydrophobic topoisomerase I inhibitor or a pharmaceutically acceptable salt thereof, and at least one polyethylene glycol (PEG) conjugated phospholipid, wherein the molar ratio of said PEG conjugated phospholipid to said hydrophobic topoisomerase I inhibitor or said pharmaceutically acceptable salt of said hydrophobic topoisomerase I inhibitor is about 0.45:1 to about 1.05:1.