The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 13, 2021
Filed:
Feb. 12, 2020
Tempus Labs, Inc., Chicago, IL (US);
Aarti Venkat, Chicago, IL (US);
Jerod Parsons, Chicago, IL (US);
Joshua S K Bell, Chicago, IL (US);
Catherine Igartua, Chicago, IL (US);
Yilin Zhang, Wilmette, IL (US);
Ameen Salahudeen, Oak Park, IL (US);
Verónica Sánchez Freire, Chicago, IL (US);
Robert Tell, Chicago, IL (US);
Tempus Labs, Inc., Chicago, IL (US);
Abstract
Methods, systems, and software are provided for determining a homologous recombination pathway status of a cancer in a test subject, e.g., to improve cancer treatment predictions and outcomes. In some embodiments, classifiers using one or more of (i) a heterozygosity status for DNA damage repair genes in a cancerous tissue, (ii) a measure of the loss of heterozygosity across the genome of the cancerous tissue, (iii) a measure of variant alleles detected in a second plurality of DNA damage repair genes in the genome of the cancerous tissue, (iv) a measure of variant alleles detected in the second plurality of DNA damage repair genes in the genome of a non-cancerous tissue, and (v) tumor sample purity are provided.