The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 13, 2021
Filed:
Apr. 16, 2018
Arizona Board of Regents on Behalf of the University of Arizona, Tucson, AZ (US);
Joe G. N. Garcia, Tucson, AZ (US);
Arizona Board of Regents on Behalf of The University of Arizona, Tucson, AZ (US);
Abstract
It has been established that inhibition of the expression and function of nicotinamide phosphoribosyltransferase (NAMPT) can treat Pulmonary Arterial Hypertension (PAH) in a patient in need thereof. Compositions and methods of an effective amount of one or more inhibitors of intracellular NAMPT (iNAMPT), extracellular NAMPT (eNAMPT), or a receptor of eNAMPT, to treat PAH are provided. The compositions and methods reduce, or reverse the physiological vascular changes associated with the onset and progression of PAH. Inhibitors of NAMPT or receptors of NAMPT include small molecules, antibodies and antigen binding fragments thereof. Dosage forms including monoclonal antibody inhibitors of NAMPT or NAMPT receptors in an amount between 10 mg and 400 mg are provided. Dosage forms including small molecule inhibitors of NAMPT in an amount between 10 mg/kg and 3.5 mg/kg body weight of the recipient are also provided.