The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 13, 2021
Filed:
May. 30, 2019
Applicant:
Cellivery Therapeutics, Inc., Seoul, KR;
Inventor:
Daewoong Jo, Brentwood, TN (US);
Assignee:
CELLIVERY THERAPEUTICS, INC., Seoul, KR;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61P 35/00 (2006.01); C07K 14/51 (2006.01); C07K 7/08 (2006.01); C07K 14/47 (2006.01); A61K 38/17 (2006.01); A61K 38/00 (2006.01); C07K 7/06 (2006.01); A61K 38/08 (2019.01); A61K 38/10 (2006.01);
U.S. Cl.
CPC ...
C07K 14/51 (2013.01); A61K 38/1761 (2013.01); C07K 7/08 (2013.01); C07K 14/47 (2013.01); C07K 14/4703 (2013.01); A61K 38/00 (2013.01); A61K 38/08 (2013.01); A61K 38/10 (2013.01); A61K 38/1709 (2013.01); C07K 7/06 (2013.01); C07K 14/4702 (2013.01); C07K 2319/00 (2013.01); C07K 2319/01 (2013.01); C07K 2319/10 (2013.01); C07K 2319/21 (2013.01); C07K 2319/40 (2013.01);
Abstract
Provided are an improved cell-permeable (iCP)-SOCS3 recombinant protein and uses thereof. Suppressor of cytokine signaling-3 (SOCS3) is an endogenous protein inhibitor of JAK/STAT pathway, and an aberrant expression of SOCS3 protein was observed in human solid tumors including gastric, colorectal and breast cancer, and glioblastoma. The iCP-SOCS3 recombinant protein provided herein may be used as protein-based anti-lung cancer agent by utilizing the platform technology for macromolecule intracellular transduction.