The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 13, 2021
Filed:
Aug. 12, 2016
Phenylsulfonamido-benzofuran derivatives and uses thereof in the treatment of proliferative diseases
Memorial Sloan-kettering Cancer Center, New York, NY (US);
Emily H. Cheng, Englewood Cliffs, NJ (US);
Paul Jeng, New Rochelle, NY (US);
Ouathek Ouerfelli, Fort Lee, NJ (US);
James Hsieh, Englewood Cliffs, NJ (US);
Guangli Yang, Syosset, NY (US);
Memorial Sloan Kettering Cancer Center, New York, NY (US);
Abstract
Described herein are phenylsulfonamido-benzofuran derivatives, and pharmaceutically acceptable salts thereof. Also provided are pharmaceutical compositions, methods, uses, and kits involving compounds of Formulae (I), (II), (III), (IV), (V), or (VI) for treating and/or preventing proliferative diseases (e.g. cancers, inflammatory diseases, and autoimmune diseases) in a subject. The compounds and pharmaceutical compositions as described herein inhibit at least one protein of the BCL-2 family in a biological sample or subject to treat and/or prevent a proliferative disease. In certain embodiments, compounds described herein are selective inhibitors of MCL-1, a BCL-2 family member protein.