The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 13, 2021
Filed:
Mar. 31, 2016
Korea Research Institute of Bioscience and Biotechnology, Daejeon, KR;
Mi Sun Won, Daejeon, KR;
Hyun Seung Ban, Daejeon, KR;
Bo Kyung Kim, Daejeon, KR;
Soon Woo Nam, Seoul, KR;
Kyeong Lee, Seoul, KR;
Young-Ju Lee, Daejeon, KR;
Hong-Sub Lee, Gyeonggi-do, KR;
Dong Uk Kim, Daejeon, KR;
Ki Cheol Park, Daejeon, KR;
Joo-Young Im, Daejeon, KR;
Kyoung-Jin Oh, Daejeon, KR;
Abstract
The present invention relates to a pharmaceutical composition for treating cancer, containing cytochrome b5 reductase 3 (CYB5R3) protein as an active ingredient. Over-expression of CYB5R3 in cancer cells results in significant reduction of hypoxia-inducible factor-1α (HIF-1α) expression, which leads inhibition of cancer cells growth in vitro and in vivo. Thus, the CYB5R3 gene or protein of the present invention can be useful as an active ingredient of a pharmaceutical composition for treating cancer.