The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 13, 2021

Filed:

Oct. 03, 2018
Applicant:

Cedars-sinai Medical Center, Los Angeles, CA (US);

Inventors:

Carol Jiurong Liang, Encino, CA (US);

Dianhua Jiang, Encino, CA (US);

Paul W. Noble, Beverly Hills, CA (US);

Assignee:

Cedars-Sinai Medical Center, Los Angeles, CA (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/20 (2006.01); A61K 31/728 (2006.01); A61K 45/06 (2006.01); A61P 11/00 (2006.01); C07K 14/54 (2006.01);
U.S. Cl.
CPC ...
A61K 38/204 (2013.01); A61K 31/728 (2013.01); A61K 45/06 (2013.01); A61P 11/00 (2018.01); C07K 14/5412 (2013.01);
Abstract

The described invention provides a method of treating a lung injury at risk of progressing to a fibrotic lung disease in a subject in need thereof comprising administering to the subject a composition comprising a therapeutic amount of IL-6 polypeptide, hyaluronan (HA), mimetics thereof, pharmaceutically acceptable salts thereof, or combinations thereof, wherein the therapeutic amount is effective to increase renewal of alveolar epithelial cell 2 (AEC2) stem cells, to repair the injury, to reduce lung fibrosis, or a combination thereof.


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