The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 13, 2021
Filed:
Nov. 01, 2016
Applicant:
Cedars-sinai Medical Center, Los Angeles, CA (US);
Inventors:
Paul W. Noble, Beverly Hills, CA (US);
Dianhua Jiang, Encino, CA (US);
Ting Xie, Los Angeles, CA (US);
Carol Jiurong Liang, Encino, CA (US);
Assignee:
CEDARS-SINAI MEDICAL CENTER, Los Angeles, CA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/713 (2006.01); C12N 15/113 (2010.01); A61K 48/00 (2006.01); A61P 11/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/713 (2013.01); A61K 48/005 (2013.01); A61K 48/0016 (2013.01); A61P 11/00 (2018.01); C12N 15/113 (2013.01); A61K 48/0058 (2013.01); A61K 48/0066 (2013.01); C12N 2310/14 (2013.01);
Abstract
The described invention provides a method for reducing progression of lung fibrosis after a lung injury comprising administering a therapeutic amount of a therapeutic agent, wherein the therapeutic amount is effective: (a) to modulate expression of a T-box transcription factor in a population of cells in lung; and (b) to reduce proliferation of the population of cells in lung expressing the T-box transcription factor. According to some embodiments the T-box transcription factor is Tbx4.