The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 13, 2021

Filed:

Aug. 04, 2017
Applicants:

Tsinghua University, Beijing, CN;

Beijing Pins Medical Co., Ltd, Beijing, CN;

Inventors:

Luming Li, Beijing, CN;

Hongyun Liu, Beijing, CN;

Zhao Yang, Beijing, CN;

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61B 5/024 (2006.01); A61B 5/00 (2006.01); A61B 5/0245 (2006.01); A61B 5/316 (2021.01); A61B 5/339 (2021.01); A61B 5/341 (2021.01); A61B 5/349 (2021.01); A61B 5/352 (2021.01);
U.S. Cl.
CPC ...
A61B 5/4094 (2013.01); A61B 5/02405 (2013.01); A61B 5/4035 (2013.01); A61B 5/4848 (2013.01); A61B 5/0245 (2013.01); A61B 5/316 (2021.01); A61B 5/339 (2021.01); A61B 5/341 (2021.01); A61B 5/349 (2021.01); A61B 5/352 (2021.01);
Abstract

A method and an apparatus for analyzing heart rate Variability (HRV), and use thereof are provided. A low-cost, portable and wearable signal acquisition device is utilized to acquire electrocardiography (ECG) signals of epilepsy patients for 24 hours before treatment, and a time domain index, a frequency domain index and a nonlinear index of the ECG during a long term and during a short term are calculated with a programmed HRV analysis method, and the efficacy of vagus nerve stimulation (VNS) treatment for patients with medically intractable epilepsy is accurately and efficiently predicted based on characteristic parameters for characterizing an effect level of the vagus nerve regulating the heart rate, i.e., vagus nerve activity, thereby avoiding unnecessary costs and avoiding the delay of the optimal treatment timing. In addition, the characteristic parameters obtained by the HRV analysis on the ECG may be utilized to clearly select VNS treatment indication patients.


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