The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 06, 2021

Filed:

Aug. 15, 2017
Applicant:

Genzyme Corporation, Cambridge, MA (US);

Inventors:

Tarl Vetter, Bridgewater, NJ (US);

Michael Coolbaugh, Bridgewater, NJ (US);

Veena Warikoo, Westford, MA (US);

Konstantin Konstantinov, Waban, MA (US);

Assignee:

Genzyme Corporation, Cambridge, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 1/34 (2006.01); B01D 61/14 (2006.01); B01D 15/18 (2006.01); C07K 16/00 (2006.01);
U.S. Cl.
CPC ...
C07K 1/34 (2013.01); B01D 15/1864 (2013.01); B01D 61/142 (2013.01); B01D 61/145 (2013.01); C07K 16/00 (2013.01); B01D 2315/16 (2013.01); C07K 2317/21 (2013.01); C07K 2317/31 (2013.01);
Abstract

Provided herein are methods of processing a fluid that include the use of one or both of a circuit system including a tangential flow filtration (TFF) unit and a circuit system including a tangential flow virus filtration (TFVF) unit. Also provided are integrated and continuous processes for manufacturing a therapeutic protein drug substance that include a step of processing a fluid including the recombinant therapeutic protein using any of the methods provided herein.


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