The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 06, 2021
Filed:
May. 14, 2018
Applicant:
Mitobridge, Inc., Cambridge, MA (US);
Inventors:
Arthur Kluge, Lincoln, MA (US);
Bharat Lagu, Acton, MA (US);
Pranab Maiti, Bangalore, IN;
Sunil Kumar Panigrahi, Hyderabad, IN;
Assignee:
Mitobridge, Inc., Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07C 311/16 (2006.01); C07D 333/38 (2006.01); C07D 309/08 (2006.01); C07D 213/81 (2006.01); C07D 233/96 (2006.01); C07D 277/56 (2006.01); C07D 307/24 (2006.01); C07D 333/24 (2006.01); C07D 237/24 (2006.01); C07D 213/56 (2006.01); C07D 263/34 (2006.01); C07D 309/06 (2006.01); C07D 233/64 (2006.01);
U.S. Cl.
CPC ...
C07C 311/16 (2013.01); C07D 213/56 (2013.01); C07D 213/81 (2013.01); C07D 233/64 (2013.01); C07D 233/96 (2013.01); C07D 237/24 (2013.01); C07D 263/34 (2013.01); C07D 277/56 (2013.01); C07D 307/24 (2013.01); C07D 309/06 (2013.01); C07D 309/08 (2013.01); C07D 333/24 (2013.01); C07D 333/38 (2013.01);
Abstract
The application relates to phenyl- or naphthylsulfonamide derivatives of the structural formula (I). The compounds are described as inhibitors of USP30 (ubiquitin specific peptidase 30) useful for the treatment of conditions involving mitochondrial defects including neurodegenerative diseases such as Alzheimer's and Parkinson's or a neoplastic disease such as leukemia.