The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 06, 2021

Filed:

Jun. 01, 2017
Applicant:

Glaxosmithkline Biologicals, S.a., Rixensart, BE;

Inventors:

Dong Yu, Rockville, MD (US);

Mayuri Sharma, Rockville, MD (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/12 (2006.01); A61K 39/39 (2006.01); C12N 15/85 (2006.01); C12N 15/86 (2006.01); C07K 14/18 (2006.01); A61P 31/14 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/12 (2013.01); A61K 39/39 (2013.01); A61P 31/14 (2018.01); C07K 14/1825 (2013.01); C12N 15/85 (2013.01); C12N 15/86 (2013.01); A61K 2039/53 (2013.01); A61K 2039/55555 (2013.01); A61K 2039/55566 (2013.01); C12N 2770/24134 (2013.01); C12N 2770/36134 (2013.01); C12N 2770/36143 (2013.01); C12N 2770/36144 (2013.01); Y02A 50/30 (2018.01);
Abstract

Compounds useful as components of immunogenic compositions for the induction of an immunogenic response in a subject against viral infection, methods for their use in treatment, and processes for their manufacture are provided herein. The compounds comprise a nucleic acid construct comprising a sequence which encodes a Zika virus antigen. A particular embodiment is a nucleic acid-based vaccine construct encoding a polypeptide comprising a full-length Zika virus prME antigen. A particular embodiment is a self-replicating RNA molecule comprising a construct encoding a polypeptide comprising a full-length Zika virus prME antigen.


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