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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10966999 B1

PDFFull Text
Date of Patent:
Apr. 06, 2021

Filed:

Dec. 19, 2018

3'3′ cyclic dinucleotides with phosphonate bond activating the sting adaptor protein

Applicant:

Institute of Organic Chemistry and Biochemistry Ascr, V.v.i., Prague, CZ;

Inventors:

Gabriel Birkus, Prague, CZ;

Ondrej Pav, Prague, CZ;

Tomas Jandusik, Prague, CZ;

Ivan Rosenberg, Prague, CZ;

Radim Nencka, Prague, CZ;

Assignee:

INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I., Prague, CZ;

Attorney:

Notaro, Michalos & Zaccaria P.C.

Primary Examiner:

Ganapathy Krishnan

Int. Cl.
CPC ...
A61K 31/7084 (2006.01); A61K 39/39 (2006.01); A61P 35/00 (2006.01); A61P 31/18 (2006.01); A61K 31/708 (2006.01); A61K 45/06 (2006.01); C07H 21/02 (2006.01);
U.S. Cl.
CPC ...
A61K 31/7084 (2013.01); A61K 31/708 (2013.01); A61K 39/39 (2013.01); A61K 45/06 (2013.01); A61P 31/18 (2018.01); A61P 35/00 (2018.01); C07H 21/02 (2013.01);
Abstract

Provided herein are the 3'3′ cyclic phosphonate dinucleotides of general formula J, their pharmaceutically acceptable salts, a pharmaceutical composition containing them and combinations of said substances and other medicaments or pharmaceuticals. The disclosure also relates to the use of said compounds for the treatment or prevention of diseases or conditions modifiable by STING protein modulation, such as cancer or viral, allergic and inflammatory diseases. In addition, these substances can be used as adjuvants in vaccines.

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