The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 06, 2021

Filed:

May. 26, 2017
Applicants:

TG Therapeutics, Inc., New York, NY (US);

Rhizen Pharmaceuticals SA, La Chaux de Fonds, CH;

Laboratoire Francais Du Fractionnement ET Des Biotechnologies, Les Ulis, FR;

Inventors:

Michael S. Weiss, New York, NY (US);

Hari P. Miskin, New York, NY (US);

Peter Sportelli, New York, NY (US);

Assignees:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4985 (2006.01); C07K 16/28 (2006.01); A61K 31/506 (2006.01); A61K 31/519 (2006.01); A61K 45/06 (2006.01); A61K 39/395 (2006.01); A61P 35/02 (2006.01); A61K 9/00 (2006.01); A61K 31/4155 (2006.01); A61K 31/416 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4985 (2013.01); A61K 9/0019 (2013.01); A61K 31/416 (2013.01); A61K 31/4155 (2013.01); A61K 31/506 (2013.01); A61K 31/519 (2013.01); A61K 39/3955 (2013.01); A61K 45/06 (2013.01); A61P 35/02 (2018.01); C07K 16/2887 (2013.01); C07K 2317/24 (2013.01); C07K 2317/41 (2013.01); C07K 2317/732 (2013.01);
Abstract

Methods for inhibiting proliferation of a B-cell population are provided comprising administering a combination of agents, comprising: (i) at least one P13K-delta selective inhibitor; (ii) at least one anti-CD20 antibody; and (iii) at least one Bruton's tyrosine kinase (BTK) inhibitor. Methods for treating B-cell proliferative disorders, such as B-cell hematological malignancies, as well as kits for carrying out the claimed methods, are also provided.


Find Patent Forward Citations

Loading…