The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 06, 2021
Filed:
Dec. 23, 2016
Applicant:
Moonshot Pharma Llc, New York, NY (US);
Inventor:
Angela Christiano, Mahwah, NJ (US);
Assignee:
MOONSHOT PHARMA LLC, New York, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/498 (2006.01); A61K 31/4245 (2006.01); A61K 39/395 (2006.01); C07K 16/28 (2006.01); A61K 31/15 (2006.01); A61K 31/427 (2006.01); A61K 31/4439 (2006.01); A61K 31/496 (2006.01); A61P 35/00 (2006.01); A61K 45/06 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/498 (2013.01); A61K 31/15 (2013.01); A61K 31/427 (2013.01); A61K 31/4245 (2013.01); A61K 31/4439 (2013.01); A61K 31/496 (2013.01); A61K 39/3955 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C07K 16/2818 (2013.01); A61K 2039/505 (2013.01); A61K 2039/507 (2013.01); A61K 2039/53 (2013.01);
Abstract
Provided herein, inter alia, are compositions and methods for generating a immune response in an individual and/or inducing the expression of neoantigens on the surface of abnormal (such as proliferative) cells via inhibition of nonsense-mediated decay (NMD) of messenger RNAs (mRNAs) bearing premature termination codons (PTCs).