The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 06, 2021

Filed:

Feb. 28, 2017
Applicant:

Jiangsu Hengrui Medicine Co., Ltd., Jiangsu, CN;

Inventors:

Yun Lu, Jiangsu, CN;

Xinhua Zhang, Jiangsu, CN;

Chenyang Wang, Jiangsu, CN;

Tonghui Liu, Jiangsu, CN;

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/437 (2006.01); A61K 9/20 (2006.01); A61K 9/16 (2006.01); A61K 47/26 (2006.01); A61K 9/50 (2006.01); A61K 47/02 (2006.01); A61K 47/12 (2006.01); A61K 47/36 (2006.01); A61K 47/44 (2017.01); A61P 35/00 (2006.01); A61P 35/04 (2006.01);
U.S. Cl.
CPC ...
A61K 31/437 (2013.01); A61K 9/1623 (2013.01); A61K 9/2018 (2013.01); A61K 9/2077 (2013.01); A61K 9/5089 (2013.01); A61K 47/02 (2013.01); A61K 47/12 (2013.01); A61K 47/26 (2013.01); A61K 47/36 (2013.01); A61K 47/44 (2013.01); A61P 35/00 (2018.01); A61P 35/04 (2018.01);
Abstract

The present invention provides a method for preparing a pharmaceutical composition containing a pyrrolo-fused six-membered heterocyclic compound or a pharmaceutically acceptable salt thereof. Specifically, the invention provides a preparation method of a pharmaceutical composition, the method containing: mixing 5-(2-diethylamino-ethyl)-2-(5-fluoro-2-oxo-1,2-dihydro-indol-3-ylidene-methyl)-3-methyl-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one or a pharmaceutically acceptable salt thereof with at least one filler, and then granulating the mixture. The pharmaceutical composition of the invention features a rapid dissolution and good stability.


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