The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 30, 2021
Filed:
Dec. 14, 2017
National Cheng Kung University, Tainan, TW;
National Cheng Kung University Hospital, Tainan, TW;
Wei-Lun Huang, Tainan, TW;
Wu-Chou Su, Tainan, TW;
Hai-Wen Chen, Tainan, TW;
Wei-Pang Chung, Tainan, TW;
I-Ting Chiang, Tainan, TW;
Te-Fu Yeh, Tainan, TW;
Hsisheng Teng, Tainan, TW;
Liang-Che Chen, Tainan, TW;
NATIONAL CHENG KUNG UNIVERSITY, Tainan, TW;
NATIONAL CHENG KUNG UNIVERSITY HOSPITAL, Tainan, TW;
Abstract
A molecular probe includes a detector molecule specific to a target molecule, and at least one label linked covalently or non-covalently to the detector molecule. The label includes a catalyst for generating electrons and/or mediators from a solution. The catalyst includes a nanomaterial, an enzyme, a metal, and/or a metal complex. The mediators can accumulate in the solution for a period of time. The detector molecule and the target molecule interact with each other by a protein based or nucleotide sequence based interaction. The mediators participate in a chemical reaction that generates a signal that may be a change in optical, electromagnetic, thermodynamic or mechanical properties. Generation efficiency of the mediators is enhanced by providing an energy to the solution. The molecular probe may be used with a molecular detection assay performed on a surface. A method for assaying the target molecule using the molecular probe is also provided.