The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 30, 2021

Filed:

Mar. 06, 2019
Applicant:

Ajinomoto Co., Inc., Tokyo, JP;

Inventors:

Hiroki Yamaguchi, Kanagawa, JP;

Kazutoshi Takahashi, Kanagawa, JP;

Moemi Tatsumi, Kanagawa, JP;

Assignee:

AJINOMOTO CO., INC., Tokyo, JP;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/09 (2006.01); C12Q 1/26 (2006.01); C12M 1/34 (2006.01); G01N 27/416 (2006.01); C12P 21/02 (2006.01); G01N 33/68 (2006.01); C12Q 1/00 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/26 (2013.01); C12M 1/34 (2013.01); C12N 15/09 (2013.01); C12P 21/02 (2013.01); C12Q 1/00 (2013.01); G01N 27/416 (2013.01); G01N 33/68 (2013.01); C12Y 113/11011 (2013.01);
Abstract

A mutated tryptophan oxidase suitable for practical implementation is described herein. Specifically, a mutated tryptophan oxidase wherein at least one amino acid residue of a wild-type tryptophan oxidase is mutated and, as a result, has higher tryptophan oxidase activity and/or stability as compared to the wild-type tryptophan oxidase. The mutated tryptophan oxidase can be derived from a wild-type tryptophan oxidase having at least one of Motifs (2), (3), (5), (7), (9), (11), (13), and (14), and at least one amino acid residue in any of these motifs can have mutation. The mutated tryptophan oxidase also can have a mutation of one or more amino acid residues in an amino acid sequence represented by SEQ ID NO: 2 and a sequence homologous thereto.


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