The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 30, 2021
Filed:
Aug. 15, 2017
Applicant:
Danmarks Tekniske Universitet, Kgs. Lyngby, DK;
Inventors:
Daniel Ley, Kgs. Lyngby, DK;
Mikael Rørdam Andersen, Farum, DK;
Helene Faustrup Kildegaard, Værløse, DK;
Assignee:
DANMARKS TEKNISKE UNIVERSITET, Lyngby, DK;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P 21/02 (2006.01); C12N 5/071 (2010.01); C12N 15/52 (2006.01); C12N 9/02 (2006.01);
U.S. Cl.
CPC ...
C12P 21/02 (2013.01); C12N 5/0682 (2013.01); C12N 15/52 (2013.01); C12Y 113/11027 (2013.01); C12N 9/0069 (2013.01);
Abstract
The present invention relates to modified producer cells for improved production of therapeutic proteins. Specifically, the inventors have found that removing genes involved in amino acid catabolism in Chinese Hamster Ovary (CHO) cells improves the cell growth and viability and likely also the yield of a recombinant therapeutic protein produced by the cells.