The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 30, 2021
Filed:
Apr. 06, 2016
Applicant:
The General Hospital Corporation, Boston, MA (US);
Inventors:
Assignee:
The General Hospital Corporation, Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); C12Q 1/6883 (2018.01); C12N 9/10 (2006.01); C12N 9/90 (2006.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); C12N 9/1007 (2013.01); C12N 9/90 (2013.01); C12Q 1/6883 (2013.01); C12Y 201/01037 (2013.01); C12Y 599/01002 (2013.01); C12N 2310/113 (2013.01); C12N 2310/14 (2013.01); C12N 2310/20 (2017.05); C12N 2310/3231 (2013.01); C12N 2310/531 (2013.01); C12N 2320/34 (2013.01); C12Q 2600/156 (2013.01);
Abstract
Methods for reactivating genes on the inactive X chromosome that include administering one or both of a DNA methyltransferase (DNMT) Inhibitor and/or a topoisomerase inhibitor, e.g., etoposide and/or 5-azacytidine (aza), optionally in combination with an inhibitor of XIST RNA and/or an Xist-interacting protein, e.g., a chromatin-modifying protein, e.g., a small molecule or an inhibitory nucleic acid (such as a small inhibitory RNA (siRNAs) or antisense oligonucleotide (ASO)) that targets XIST RNA and/or a gene encoding an Xist-interacting protein, e.g., a chromatin-modifying protein.