The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 30, 2021
Filed:
Jan. 18, 2019
Applicant:
Amicus Therapeutics, Inc., Cranbury, NJ (US);
Inventors:
Russell Gotschall, Doylestown, PA (US);
Hung V. Do, New Hope, PA (US);
Assignee:
Amicus Therapeutics, Inc., Cranbury, NJ (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/40 (2006.01); A61K 48/00 (2006.01); C12N 15/09 (2006.01); A61P 43/00 (2006.01); A61P 3/08 (2006.01);
U.S. Cl.
CPC ...
C12N 9/2465 (2013.01); A61K 48/005 (2013.01); C12N 15/09 (2013.01); C12Y 302/0102 (2013.01); C12N 2510/02 (2013.01);
Abstract
Recombinant human alpha glucosidase (rhGAA) composition derived from CHO cells that contains a more optimized glycan composition consisting of a higher amount of rhGAA containing N-glycans carrying mannose-6-phosphate (M6P) or bis-M6P than conventional rhGAAs, along with low amount of non-phosphorylated high mannose glycans, and low amount of terminal galactose on complex oligosaccharides. Compositions containing the rhGAA, and methods of use are described.