The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 30, 2021
Filed:
Nov. 04, 2016
Asymchem Laboratories (Tianjin) Co., Ltd., Tianjin, CN;
Asymchem Life Science (Tianjin) Co., Ltd., Tianjin, CN;
Tianjin Asymchem Pharmaceuticals Co., Ltd., Tianjin, CN;
Asymchem Laboratories (Fuxin) Co., Ltd., Liaoning, CN;
Jilin Asymchem Laboratories Co., Ltd., Jilin, CN;
Hao Hong, Tianjin, CN;
Gage James, Tianjin, CN;
Jiangping Lu, Tianjin, CN;
Na Zhang, Tianjin, CN;
Wenyan Yu, Tianjin, CN;
Fang Liu, Tianjin, CN;
Yanjun Li, Tianjin, CN;
Xin Huang, Tianjin, CN;
Juan Gao, Tianjin, CN;
Kejian Zhang, Tianjin, CN;
Yulei Ma, Tianjin, CN;
Junlu Wei, Tianjin, CN;
ASYMCHEM LABORATORIES (TIANJIN) CO., LTD., Tianjin, CN;
ASYMCHEM LIFE SCIENCES (TIANJIN) CO., LTD., Tianjin, CN;
TIANJIN ASYMCHEM PHARMACEUTICALS CO., LTD., Tianjin, CN;
ASYMCHEM LABORATORIES (FUXIN) CO., LTD., Fuxin, CN;
JILIN ASYMCHEM LABORATORIES CO., LTD., Jilin, CN;
Abstract
Provided are a proline hydroxylase and uses thereof. The proline hydroxylase comprises (a) a protein having the amino acid sequence as shown in SEQ ID NO: 2; (b) a protein having an amino acid sequence of SEQ HD NO: 2 with a mutation of one or more amino acids and having a proline hydroxylase activity; or (c) a protein retaining the mutation of one or more amino acids as in (b), and having the proline hydroxylase activity and having at least 78% homology with the amino acid sequence of the protein in (b). Protein having the amino acid sequence as shown in SEQ HD NO: 2 and mutants obtained by genetically engineering have higher catalytic specificity or significantly increased catalytic activity when compared to proline hydroxylases in prior art.