The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 30, 2021
Filed:
Nov. 29, 2019
The University of Copenhagen, Copenhagen K, DK;
Memorial Sloan-kettering Cancer Center, New York, NY (US);
Anja Groth, Copenhagen N, DK;
Giulia Saredi, Copenhagen N, DK;
Hongda Huang, New York, NY (US);
Colin Hammond, Copenhagen N, DK;
Dinshaw Patel, New York, NY (US);
The University of Copenhagen, Copenhagen K, DK;
Memorial Sloan-Kettering Cancer Center, New York, NY (US);
Abstract
The present invention relates to small molecules interfering with the conformational space of the TONSL ARD occupied by the histone H4 tail. These small molecules targets the binding pocket of TONSL encompassing the H4 residues K12-R23 and act by preventing or disrupting the binding of the H4 tail K12-R23 with the TONSL ARD via direct competition or via allosteric disruption of the binding pocket.