The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 30, 2021
Filed:
Aug. 06, 2018
Applicant:
Heidelberg Pharma Research Gmbh, Ladenburg, DE;
Inventors:
Christian Lutz, Ladenburg, DE;
Werner Simon, Ladenburg, DE;
Susanne Werner-Simon, Ladenburg, DE;
Christoph Müller, Ladenburg, DE;
Torsten Hechler, Ladenburg, DE;
Michael Kulke, Ladenburg, DE;
Assignee:
Heidelberg Pharma Research GmbH, Ladenburg, DE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 7/64 (2006.01); A61K 47/68 (2017.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 7/64 (2013.01); A61K 47/6831 (2017.08); A61K 38/00 (2013.01);
Abstract
The invention relates to novel methods for synthesizing amanitin derivatives having a hydroxy group attached to the central tryptophan moiety. The invention furthermore relates to novel amanitin derivatives having a hydroxy group attached to position 4', 5′ or 7′ of the central tryptophan moiety, novel conjugates of such amanitin derivatives, and pharmaceutical compositions comprising such conjugates.