The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 30, 2021
Filed:
Mar. 16, 2017
Applicant:
Ionis Pharmaceuticals, Inc., Carlsbad, CA (US);
Inventors:
Richard Lee, Oceanside, CA (US);
Jeffrey R. Crosby, Carlsbad, CA (US);
Assignee:
Ionis Pharmaceuticals, Inc., Carlsbad, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/02 (2006.01); A61K 31/7125 (2006.01); A61K 31/7115 (2006.01); A61K 31/713 (2006.01); A61K 31/712 (2006.01); C07H 21/04 (2006.01); C12N 15/113 (2010.01); A61P 9/10 (2006.01); A61P 25/28 (2006.01); A61P 11/06 (2006.01); A61P 3/10 (2006.01); A61P 29/00 (2006.01);
U.S. Cl.
CPC ...
C07H 21/02 (2013.01); A61K 31/712 (2013.01); A61K 31/713 (2013.01); A61K 31/7115 (2013.01); A61K 31/7125 (2013.01); A61P 3/10 (2018.01); A61P 9/10 (2018.01); A61P 11/06 (2018.01); A61P 25/28 (2018.01); A61P 29/00 (2018.01); C07H 21/04 (2013.01); C12N 15/113 (2013.01); C12N 15/1138 (2013.01); C12N 2310/11 (2013.01); C12N 2310/315 (2013.01); C12N 2310/3231 (2013.01); C12N 2310/341 (2013.01); C12N 2310/346 (2013.01); C12N 2320/30 (2013.01);
Abstract
Provided herein are methods, compounds, and compositions for reducing expression of KEAP1 in animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate oxidative stress or a disease, disorder or condition related to oxidative stress an animal in need. Diseases, disorders or conditions related to oxidative stress include NASH, NAFLD, asthma and insulin resistance.