The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 30, 2021

Filed:

Jan. 03, 2018
Applicant:

Bristol-myers Squibb Company, Princeton, NJ (US);

Inventors:

Robert M. Borzilleri, Carversville, PA (US);

Upender Velaparthi, Princeton Junction, NJ (US);

Chetan Padmakar Darne, Ewing, NJ (US);

Peiying Liu, Marlborough, MA (US);

Manjunatha Narayana Rao Kamble, Bangalore, IN;

Balaji Seshadri, Hosur, IN;

Raju Mannoori, Bangalore, IN;

Hasibur Rahaman, Bangalore, IN;

Jayakumar Sankara Warrier, Bangalore, IN;

Assignee:

Bristol-Myers Squibb Company, Princeton, NJ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); C07D 401/14 (2006.01); C07D 471/04 (2006.01); A61K 45/06 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); C07D 401/14 (2013.01); C07D 487/04 (2013.01); A61K 45/06 (2013.01); C07K 16/2818 (2013.01);
Abstract

The invention relates generally to compounds of formula (I) that modulate the activity of TGFβR-1 and TGFβR-2, pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.


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