The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 30, 2021
Filed:
Dec. 19, 2017
Applicant:
Lifearc, London, GB;
Inventors:
Simon Osborne, London, GB;
Jonathan Large, London, GB;
Assignee:
LIFEARC, London, GB;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 263/48 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01); C07D 487/04 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 413/14 (2013.01); C07D 263/48 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01); C07D 487/04 (2013.01); A61K 45/06 (2013.01);
Abstract
A first aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, wherein: •B is an aryl or heteroaryl group optionally substituted by one or more Rgroups; and *X is selected from 0, (CRR)p and (CRR)p CO. Said compounds are capable of inhibiting PAICS and are useful in the treatment of proliferative disorders. Further aspects relate to pharmaceutical compositions, therapeutic uses and process for preparing compounds of formula (I).