The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 30, 2021
Filed:
Jul. 20, 2017
Nanjing Sanhome Pharmaceutical Co., Ltd., Nanjing, Jiangsu, CN;
Yong Wang, Nanjing, CN;
Liwen Zhao, Nanjing, CN;
Xiaorong Liu, Nanjing, CN;
Yan Zhang, Nanjing, CN;
Dandan Huang, Nanjing, CN;
Chunhuan Jiang, Nanjing, CN;
Xinsheng Shi, Nanjing, CN;
Hongfeng Gu, Nanjing, CN;
Silin Pang, Nanjing, CN;
Wei Hai, Nanjing, CN;
Bingyang Ge, Nanjing, CN;
NANJING SANHOME PHARMACEUTICAL CO., LTD., Jiangsu, CN;
Abstract
Provided are a chemical compound of an isocitrate dehydrogenase inhibitor, and an application thereof, belonging to the field of medicinal chemistry; specifically provided is the chemical compound represented by formula I, or its isomer, pharmaceutically acceptable salt, crystal, solvate, or prodrug, as well as their preparation methods and pharmaceutical compositions containing said chemical compound, and an application of said chemical compound or composition. The chemical compound has very good ability to inhibit mutant IDH2 enzyme activity and to inhibit mutant IDH2 neoplastic cells, and may be used for preventing and/or treating a tumor characterized by the presence of mutant IDH2.